[Cytometry] COG samples-MRD

Saba Jamal sabajamal at hotmail.com
Tue May 10 13:34:06 EDT 2011


Where can I get the COG protocol
 
Saba
 
> Date: Tue, 26 Apr 2011 13:12:44 -0400
> From: Brian.Marsiglia at inova.org
> To: mir9079 at med.cornell.edu
> CC: cytometry at lists.purdue.edu
> Subject: Re: [Cytometry] COG samples-MRD
> 
> I agree. Our analytical sensitivity is at 2 places. When we set up our
> validations over a year ago, I adopted the COG protocol for flow. My
> concern was that clinical decisions are being made at the 0.1 level.
> Why report a value when the "action" sensitivity is only at one place?
> Maybe I'm now wrong, and clinicians are actually acting on a 0.01
> sensitivity.
> 
> 
> 
> ________________________________
> 
> From: Mikhail Roshal [mailto:mir9079 at med.cornell.edu] 
> Sent: Tuesday, April 26, 2011 1:04 PM
> To: Marsiglia, Brian
> Cc: Cytometry list
> Subject: Re: [Cytometry] COG samples-MRD
> 
> 
> 
> Brian,
> 
> The answer is a bit complicated. You need to know what YOUR analytical
> sensitivity is. That depends on how good your panels are. How many cells
> can you acquire etc... You may not have the sensitivity or the
> specificity to report that kind of data. There is certainly a good body
> data in ALL that sub 0.1% MRD levels are significant and can be detected
> by flow (see Blood. 2008 Jun 15;111(12):5477-85 for one example) and a
> few centers can do it. Data is also emerging in AML (J Clin Oncol. 2011
> Mar 20;29(9):1190-7). 
> 
> Misha
> 
> On Apr 26, 2011, at 12:42 PM, Marsiglia, Brian wrote:
> 
> 
> 
> 
> 
> 
> Is anyone here reporting MRD's on Peds. Samples, clinically? If you
> are, how many decimal places are you going to?
> 
> I know in PCR, many labs are reporting to 2 decimal places, but I don't
> know of any clinical flow labs reporting to 2 decimal places.
> 
> I'm being told by our pediatric oncology team that any peer review which
> suggests reporting to 1 decimal place is "dated" and that we need to
> increase our sensitivity.
> 
> Any feed back would be appreciated. 
> 
> -Brian
> 
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> 
> 
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