Antibodies for malignant plasma cells
Edwards, Leonel, M.D.
Leonel.Edwards at danhosp.org
Thu Dec 6 09:26:54 EST 2001
The same here. However in my practice environment oncologists submit a good
number of bone marrow biopsies as part of the evaluation of a patient with a
monoclonal spike. In these cases the plasma cell count is between 5 and
10%. It is very difficult to detect clonality by immunohistochemistry or to
infer plasma cell dyscrasia by morphology alone. Flow Cytometry can
definitely add significant information to these cases. Good articles are
available that discuss some of the benefits. I am sure there will be more.
Leonel Edwards, M.D.
Clinical Immunology, Flow Cytometry and Molecular Pathology Laboratories
Department of Pathology and Laboratory Medicine
From: Timothy Singleton, M.D. [mailto:tsingleton at smtpgw.beaumont.edu]
Sent: Monday, December 03, 2001 5:29 PM
To: Cytometry Mailing List
Subject: Re: Antibodies for malignant plasma cells
I have mixed feelings about performing flow cytometry for monoclonal
These patients all have monoclonal plasma cells. Phenotyping just documents
clone is detectable by flow cytometry and whether there might be a
that correlates with malignancy. Flow cytometry might not be necessary for
>From a patient care perspective multiple myeloma is incurable, except
possibly for newer
modalities, such as allogeneic bone marrow transplant. Some clinical
recommend following the patients and waiting for clinical signs of disease
(anemia, lytic bone lesions, etc.) to decide when to initiate treatment.
Tim Singleton, MD
Royal Oak, MI
>>> "Andrea Illingworth" <dcdsflow at mint.net> 11/30/01 04:03PM >>>
What are your thoughts on the use of CD40 to differentiate normal plasma
Currently we are using the CD45/CD56/CD38 combination but we are looking
adding CD138 and/or CD40. Would you recommend one over the other or
Thank you for your input!
Dahl-Chase Flow Cytometry
Bangor, Maine 04401
Andrea_Illingworth at dahlchase.com
More information about the Cytometry