blocking antibody against CTLA-4

kiani@oncocenter.de kiani at oncocenter.de
Thu Sep 14 12:28:21 EST 2000


Dear Flowers,

although this is not an exactly flow-related question: does anybody know of
a commercial or non-commercial source of a blocking antibody against human
CTLA-4 (CD152), as well as an activating antibody against human CD40 ? Both
antibodies are intended to be used in cocultures of T cells and
antigen-pulsed APCs in vitro.

With regard to anti-CTLA-4: I would like to use the antibody to selectively
block CTLA-4/ B7 interactions between T cells and APCs, while leaving CD28/
B7 interactions intact (in contrast to the fusion protein CTLA-4-Ig which
blocks both).

Thanks in advance for any help.

Alex

Alexander Kiani, MD
Medizinische Klinik und Poliklinik I
Technische Universität Dresden
Fetscherstr. 74
D - 01307 Dresden
Germany
Tel. +49-351-458-5617, -3610, -3311
Fax +49-351-458-5370
E-mail: kiani at oncocenter.de




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