In search of Human Neutrophil Apoptotic inducers

Kuhnmuench, John jkuhnmue at mail.mcw.edu
Thu Sep 7 11:23:37 EST 2000


Hello All,
I am having some trouble finding a reliable apoptotic inducing ligand,
reagent, etc. That I can use on human neutrophils and that is also relativly
fast acting.  We are using the ApoAlert system from Clontech. What I need is
something that will induce apoptosis quickly.  We are looking at a number of
different compounds that may inhibit apoptosis,  and because of the
relativly short lifespan of these neutrophils we need something speedy, yet
won't overwhelm the cells and cause them all to all die immediatly.  Any
help would be greatly appreciated.

Thank you,

John R. Kuhnmuench III
Medical College of Wisconsin
Department of Pathology
ImmunoPathology Research Laboratory
Froedtert West Hospital
9200 W. Wisconsin Ave.
Milwaukee, WI 53226
Ph. 805-2678




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