unexpected T and B phenotypes after culture

James Weaver 301-594-5879 FAX 301-594-3037 WEAVER at CDER.FDA.GOV
Wed Apr 19 08:35:06 EST 2000


We have on rare occasions observed a significant population (~30% vs <
0.5% normal) of mouse periperal blood leukocytes that appear to
co-express TcR-Beta and CD-45R (B-220). This is a transient event as the
same mice sampled 3 days later do not show this population. The CD4 and
CD8 percentages in these mice were normal. I have also heard anecdotal
reports of a similar response following in vivo stimulation with Staph
enterotoxin B.

-Jim Weaver


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* James L. Weaver Ph.D.				*
* Division of Applied Pharmacology Research	*
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