Hybridoma mAb production mini-bio-reactors

Matthias Haury mhaury at igc.gulbenkian.pt
Wed Sep 8 13:22:49 EST 1999


Hello everybody,

I would like to buy one of this hybridoma mini-bio-reactors that you can
use to obtain on a small scale high mAb concentrations for custom mAb
production and purification. I have heard that some of this machines are
easier to use than others and have less risks of contamination... therefore
I would like to know if some of you have experience with this and what
model of those culture chambers you are using.
Just to make myself clear, I don't want a real bio-reactor but one of this
devices that allow you to grow high density of hybridomas and recovering
the supernatents with high antibody concentrations, typically to produce a
couple of mg of an custom antibody in concentrations of about 10 mg/ml...

I'd be very happy to get some suggestions on which are the better of those
devices.

Thanks very much in advance. If others are interested I can post the
summary to the list (just send me a mail directly).

cheers,

Matthias

_____________________________________
Dr. Matthias Haury
Instituto Gulbenkian de Ciencia
Unidade de Imagiologia Celular
Rua Da Quinta Grande N° 6 - Apt.14
P-2781 Oeiras Codex
Portugal
Email: mhaury at igc.gulbenkian.pt
Tel: + 351 (01) 440 79 85 Office
Tel: + 351 (01) 440 79 10 Secretary
Fax: + 351 (01) 440 79 70
_____________________________________








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