CD23 expression on T-cells
DAHL CHASE DIAGNOSTIC SERVICES
dcdsflow at mint.net
Mon Dec 28 15:10:15 EST 1998
I posted this about 2 weeks ago but have not had any responses. So I am
trying it again just in case something went wrong with my e-mail and it
didn't get sent.
Dear clinical collegues, we need your help again!
We just analyzed the peripheral blood of a 52 year old gentleman which came
to our lab for a CLL work-up.
WBC: 2.0 RBC: 4.21 HGB: 13.9 PLT: 54 19% grans 66%lymphs 7% monos/eos
As you can see, the patient has a definite neutropenia/thrombocytopenia and
not an absolute lymphocytosis but we ran it anyway. The flow analysis of
the brightly CD45+ lymphocytes showed approx. 94% T-lymphocytes (CD2+, CD3+,
CD5+, CD7+) with 48% CD4 and 44% CD8. 5% B-cells were also identified with
2% kappa and 2% lambda. However, about 15% of the lymphocytes also exhibit
CD23/CD7, CD23/CD3 and CD23/CD5. There is no CD19/CD5 coexpression! The
CD23 expression was not seen on the CD4 lymphs. I couldn't perform the
CD23/CD8 and the CD23/CD2 because we don't carry this color combination but
I am assuming that these cells are also pos for CD2 and CD8. I am really at
a loss since I have never seen this strange coexpression. Is this just
atypical or abnormal (?malignant)?
We appreciate your input
Dahl-Chase Diagnostic Services/Flow Cytometry
333 State Street
Bangor, Maine 04401
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