Oleg S. Vasilyev
mathmed at bsd.ropnet.ru
Wed Nov 13 23:12:33 EST 1996
In many of laboratories (by the publications) histograms (flow
cytometry) estimate as percent of positive crates. However, such way of
an estimation histograms too rough, we lose a lot of biological
information. Through mathematical modeling it is possible to receive a
clearer picture of a condition immune system.
Such approach can be applied at exacter diagnostics of a condition
immune system and at study of influence per capita of new medicines.
For the analysis we use histograms with large dispersion
(heterogeneity) such as HLA-DR/CD4 + T-cells and so on (have long "tail"
from active (HLA-DR positive) cells).
On reaction CD4 + T-cells on an antigene we can indirectly judge
reaction immune system and person as a whole on an antigene. In such a
way it is possible to test new medicines.
On financial difficulties we can not now carry out(spend) experimental
If YOU were interested by(with) such approach , can be YOU send
For the given patient with a known pathology or before and after
medicinal therapy (it is unimportant which) are necessary histograms
peripherical blood T-cells:
1. HLA-DR/CD4 +
2. HLA-DR/CD4 + /CD45RA - naiv cells
For an estimation of influence of a given medicinal means it is
necessary to have histograms from several (~20) patients and control
histograms of the donors.
If YOU investigate a given pathology or test a medicinal means, we shall
be glad to give you result of our analysis.
We sincerely hope for further cooperation.
With deep respect
Oleg S. Vasilyev
NATIONAL RESERCH CENTR-INSTITUTE OF IMMUNOLIOGY
Mathmed at ropnet.ru
More information about the Cytometry