hematagones vs ALL?
Bruce Davis, MD - Clinical Pathology
bdavis at beaumont.edu
Fri Mar 22 18:00:32 EST 1996
My approach, similar to that done by Cytometry Associates, is to recognize
presursor B cells or hematogones by their characteristic profile as
CD38++, CD10+, CD19+, sIg-, Fc receptor negative, CD20- or dim, and a cluster
often found southwest of lymhocytes on a CD45/log side scatter display. I
find the CD10, CD38, CD45 combination particularly useful. With this
approach you should have no problem distinquishing ALL from normal precusor
B cells down to a level of 2-3%. For detection below 2%, I would feel better
knowing the original antigenic fingerprint of the ALL clone.
Bruce H. Davis, M.D.
Wm Beaumont Hosp.
More information about the Cytometry