T Cell Lymphoma?

Frederic Preffer preffer at HELIX.MGH.HARVARD.EDU
Tue Mar 12 17:36:51 EST 1996


>Date: Tue, 12 Mar 1996 17:28:57
>To: Mazharov <vmazha at osprey.unf.edu>
>From: Frederic Preffer <preffer at helix.mgh.harvard.edu>
>Subject: Re: T Cell Lymphoma?
>
>I think you are probably on the right track with respect to a T cell
malignancy, which should be clonal by molecular techniques. Is the CD4
COEXPRESSED with the CD8? In either case, I would be curious to know if CD1,
CD2 and TdT were present.What about cytoplasmic TCR? Obviously, if DNA
aneuploid you could better make the call of malignancy w/out
clonal-molecular studies.
>
>-----------------------------------
>At 07:24 AM 3/12/96 -0500, you wrote:
>>Hello Everyone!
>>
>>I got some difficulties with one case.
>> 
>>77 year old male.
>>In peripheral blood we found:
>>All B Cells markers  are negative.
>>CD5, CD7, CD3(surface), CD10, CD14, CD16+56, CD25, CD34 are negative also.
>>CD4, CD3(cytoplasmic), CD38, CD8 are bright positive.
>>CD8 is dim positive. CD45 is dim also.
>>
>>I'll be glad to get any suggestions.
>>
>>Thanks in advance.
>>
>>Mike
>>
>
`````````````````````````````````````````````````
         Frederic I. Preffer
preffer at helix.mgh.harvard.edu
Department of Pathology- Cox5
100 Blossom St
Massachusetts General Hospital
Boston MA 02114
   (617) 726-7481  {fax x2365}
~~~~~~~~~~~~~~~~~~~~~~~~~~~




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